Novel Use Of Glycosylation Scanning To Map The Intracellular Trafficking Of Sarco(Endo)Plasmic Reticulum Calcium At Pase 1 A Rory J., Flinn

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Published: 2006

Paperback

82 pages


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Novel Use Of Glycosylation Scanning To Map The Intracellular Trafficking Of Sarco(Endo)Plasmic Reticulum Calcium At Pase 1 A  by  Rory J., Flinn

Novel Use Of Glycosylation Scanning To Map The Intracellular Trafficking Of Sarco(Endo)Plasmic Reticulum Calcium At Pase 1 A by Rory J., Flinn
2006 | Paperback | PDF, EPUB, FB2, DjVu, audiobook, mp3, ZIP | 82 pages | ISBN: | 3.52 Mb

The sarco(endo)plasmic reticulum calcium ATPase (SERCA) family of proteins function as calcium pumps in the endoplasmic reticulum (ER) and sarcoplasmic reticulum (SR) membranes. SERCA1a is found exclusively in fast-twitch muscle cells and mediatesMoreThe sarco(endo)plasmic reticulum calcium ATPase (SERCA) family of proteins function as calcium pumps in the endoplasmic reticulum (ER) and sarcoplasmic reticulum (SR) membranes. SERCA1a is found exclusively in fast-twitch muscle cells and mediates muscle relaxation by pumping calcium back into the SR after calcium has been released into the cytoplasm to elicit muscle contraction.

The mechanism which allows SR biogenesis is not known, but SR membrane is believed to bud from the ER. One hypothesis is that SERCA1a proteins play a significant role in SR biogenesis in fast-twitch skeletal muscle due the proteins large size and clustering into large arrays in the SR membrane. SERCA1a arrays could recruit lipids which would allow for a large increase in membrane size that could result in the formation of the SR. Also, SERCA1a is highly expressed during the early stages of myogenesis, at the same time the first emergence of the SR is observed.

(Abstract shortened by UMI.)



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